In vivo time-lapse imaging of mitochondria in healthy and diseased peripheral myelin sheath.
作者： Sergio Gonzalez , Ruani Fernando , Jade Berthelot , Claire Perrin-Tricaud , Emmanuelle Sarzi
DOI: 10.1016/J.MITO.2015.05.004
关键词: Homeostasis 、 Biology 、 Mitochondrion 、 Immunology 、 Mutant 、 Preclinical imaging 、 Cell biology 、 In vivo 、 Biomarker (cell) 、 Myelin 、 Organelle
摘要: Abstract The myelin sheath that covers a large amount of neurons is critical for their homeostasis, and myelinating glia mitochondria have recently been shown to be essential neuron survival. However morphological physiological properties these organelles remain elusive. Here we report method analyze mitochondrial dynamics morphology in Schwann cells living mice using viral transduction time-lapse multiphoton microscopy. We describe the distribution, shape, size live cells. also alterations Opa1 delTTAG mutant at presymptomatic stages, suggesting defects contribute OPA1 related neuropathy represent biomarker disease.
sci-hub.se 参考文章(44)
Takashi Okada, Mutsuko Nonaka-Sarukawa, Ryosuke Uchibori, Kazue Kinoshita, Hiromi Hayashita-Kinoh, Yuko Nitahara-Kasahara, Shin'ichi Takeda, Keiya Ozawa, Scalable purification of adeno-associated virus serotype 1 (AAV1) and AAV8 vectors, using dual ion-exchange adsorptive membranes. Human Gene Therapy. ,vol. 20, pp. 1013- 1021 ,(2009) , 10.1089/HUM.2009.006
M. Ozcelik, L. Cotter, C. Jacob, J. A. Pereira, J. B. Relvas, U. Suter, N. Tricaud, Pals1 Is a Major Regulator of the Epithelial-Like Polarization and the Extension of the Myelin Sheath in Peripheral Nerves The Journal of Neuroscience. ,vol. 30, pp. 4120- 4131 ,(2010) , 10.1523/JNEUROSCI.5185-09.2010
Julien Cassereau, Arnaud Chevrollier, Naïg Gueguen, Valérie Desquiret, Christophe Verny, Guillaume Nicolas, Frédéric Dubas, Patrizia Amati-Bonneau, Pascal Reynier, Dominique Bonneau, Vincent Procaccio, Mitochondrial dysfunction and pathophysiology of Charcot–Marie–Tooth disease involving GDAP1 mutations Experimental Neurology. ,vol. 227, pp. 31- 41 ,(2011) , 10.1016/J.EXPNEUROL.2010.09.006
Michelle Barbi de Moura, Lucas Santana dos Santos, Bennett Van Houten, Mitochondrial dysfunction in neurodegenerative diseases and cancer. Environmental and Molecular Mutagenesis. ,vol. 51, pp. 391- 405 ,(2010) , 10.1002/EM.20575
N. Ohno, G. J. Kidd, D. Mahad, S. Kiryu-Seo, A. Avishai, H. Komuro, B. D. Trapp, Myelination and Axonal Electrical Activity Modulate the Distribution and Motility of Mitochondria at CNS Nodes of Ranvier The Journal of Neuroscience. ,vol. 31, pp. 7249- 7258 ,(2011) , 10.1523/JNEUROSCI.0095-11.2011
Aurélien Olichon, Laurent Baricault, Nicole Gas, Emmanuelle Guillou, Annie Valette, Pascale Belenguer, Guy Lenaers, Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis Journal of Biological Chemistry. ,vol. 278, pp. 7743- 7746 ,(2003) , 10.1074/JBC.C200677200
Romain Cartoni, Jean-Claude Martinou, Role of mitofusin 2 mutations in the physiopathology of Charcot-Marie-Tooth disease type 2A. Experimental Neurology. ,vol. 218, pp. 268- 273 ,(2009) , 10.1016/J.EXPNEUROL.2009.05.003
Daniel J. Christensen, Maiken Nedergaard, Two-photon in vivo imaging of cells Pediatric Nephrology. ,vol. 26, pp. 1483- 1489 ,(2011) , 10.1007/S00467-011-1818-9
Barbara Zonta, Steven Tait, Shona Melrose, Heather Anderson, Sheila Harroch, Jennifer Higginson, Diane L. Sherman, Peter J. Brophy, Glial and neuronal isoforms of Neurofascin have distinct roles in the assembly of nodes of Ranvier in the central nervous system. Journal of Cell Biology. ,vol. 181, pp. 1169- 1177 ,(2008) , 10.1083/JCB.200712154
Pascale Belenguer, Luca Pellegrini, The dynamin GTPase OPA1: More than mitochondria? ☆ Biochimica et Biophysica Acta. ,vol. 1833, pp. 176- 183 ,(2013) , 10.1016/J.BBAMCR.2012.08.004