Allethrin induced toxicity in the male reproductive tract of rats contributes to disruption in the transcription of genes involved in germ cell production

作者: Golla Madhubabu , Suresh Yenugu

DOI: 10.1002/TOX.21864

关键词: Internal medicineGlutathione peroxidaseOxidative stressBiologyLipid peroxidationSpermatogenesisEndocrinologySpermEpididymisToxicitySuperoxide dismutase

摘要: Pyrethroids are known to be neurotoxic. However, their toxic effects including that of allethrin on the male reproductive tract not elucidated. Adult rats were treated orally with 25, 50, 100, and 150 mg/kg body weight every day for 60 days. Lipid peroxidation was increased (p < 0.001) in caput, cauda, testes. Nitric oxide production but unaltered cauda The activities catalase, glutathione peroxidase, glutathione-S-transferase, superoxide dismutase decreased caput where as a decrease observed testis obtained from rats. In epididymides testes, damage tubular architecture, congestion, degeneration epithelial cell lining, intestinal edema, presence dead or degenerating spermatids dose dependent manner. expression profile genes involved spermatogenesis (Tgf-beta1), sperm maturation (Spag11e), function (Defb22) reduced p53 gene phosphorylation MAPK (p42/p44) tissues Although earlier studies have reported inhalation because use mosquito coils vaporizers, our results first time prove oral exposure could affect fertility may contribute deregulation cycle tract. © 2013 Wiley Periodicals, Inc. Environ Toxicol 29: 1330–1345, 2014.

参考文章(57)
Hugo Aebi, Catalase in vitro Methods in Enzymology. ,vol. 105, pp. 121- 126 ,(1984) , 10.1016/S0076-6879(84)05016-3
Farer Ls, Dugan Jb, Roisin A, Kafrissen Me, Sattin Rw, Epidemic of gynecomastia among illegal Haitian entrants. Public Health Reports. ,vol. 99, pp. 504- 510 ,(1984)
M. Lepoivre, B. Chenais, A. Yapo, G. Lemaire, L. Thelander, J.P. Tenu, Alterations of ribonucleotide reductase activity following induction of the nitrite-generating pathway in adenocarcinoma cells. Journal of Biological Chemistry. ,vol. 265, pp. 14143- 14149 ,(1990) , 10.1016/S0021-9258(18)77279-7
William B. Jakoby, The Glutathione S -Transferases: A Group of Multifunctional Detoxification Proteins Advances in Enzymology - and Related Areas of Molecular Biology. ,vol. 46, pp. 383- 414 ,(1978) , 10.1002/9780470122914.CH6
F Ben Abdallah, A Ben Slima, I Dammak, L Keskes‐Ammar, Z Mallek, None, Comparative effects of dimethoate and deltamethrin on reproductive system in male mice. Andrologia. ,vol. 42, pp. 182- 186 ,(2010) , 10.1111/J.1439-0272.2009.00976.X
Ramazan Bal, Mustafa Naziroğlu, Gaffari Türk, Ökkes Yilmaz, Tuncay Kuloğlu, Ebru Etem, Giyasettin Baydas, Insecticide imidacloprid induces morphological and DNA damage through oxidative toxicity on the reproductive organs of developing male rats Cell Biochemistry and Function. ,vol. 30, pp. 492- 499 ,(2012) , 10.1002/CBF.2826
Joe M. McCord, Irwin Fridovich, Superoxide Dismutase AN ENZYMIC FUNCTION FOR ERYTHROCUPREIN (HEMOCUPREIN) Journal of Biological Chemistry. ,vol. 244, pp. 6049- 6055 ,(1969) , 10.1016/S0021-9258(18)63504-5
Chargui Issam, Haouas Zohra, Zaouali Monia, Ben Cheikh Hassen, Effects of dermal sub-chronic exposure of pubescent male rats to permethrin (PRMT) on the histological structures of genital tract, testosterone and lipoperoxidation. Experimental and Toxicologic Pathology. ,vol. 63, pp. 393- 400 ,(2011) , 10.1016/J.ETP.2010.02.016
Giovanni Pontecorvo, Stefania Fantaccione, Recombinogenic activity of 10 chemical compounds in male germ cells of Drosophila melanogaster. Ecotoxicology and Environmental Safety. ,vol. 65, pp. 93- 101 ,(2006) , 10.1016/J.ECOENV.2005.05.022