作者: Golla Madhubabu , Suresh Yenugu
DOI: 10.1002/TOX.21864
关键词: Internal medicine 、 Glutathione peroxidase 、 Oxidative stress 、 Biology 、 Lipid peroxidation 、 Spermatogenesis 、 Endocrinology 、 Sperm 、 Epididymis 、 Toxicity 、 Superoxide dismutase
摘要: Pyrethroids are known to be neurotoxic. However, their toxic effects including that of allethrin on the male reproductive tract not elucidated. Adult rats were treated orally with 25, 50, 100, and 150 mg/kg body weight every day for 60 days. Lipid peroxidation was increased (p < 0.001) in caput, cauda, testes. Nitric oxide production but unaltered cauda The activities catalase, glutathione peroxidase, glutathione-S-transferase, superoxide dismutase decreased caput where as a decrease observed testis obtained from rats. In epididymides testes, damage tubular architecture, congestion, degeneration epithelial cell lining, intestinal edema, presence dead or degenerating spermatids dose dependent manner. expression profile genes involved spermatogenesis (Tgf-beta1), sperm maturation (Spag11e), function (Defb22) reduced p53 gene phosphorylation MAPK (p42/p44) tissues Although earlier studies have reported inhalation because use mosquito coils vaporizers, our results first time prove oral exposure could affect fertility may contribute deregulation cycle tract. © 2013 Wiley Periodicals, Inc. Environ Toxicol 29: 1330–1345, 2014.