Immunological studies of plasma protease inhibitors associated with human blood platelets

作者: G.K.M. Endresen

DOI: 10.1016/0049-3848(80)90415-6

关键词: PlateletMolecular biologyMacroglobulinProteaseAntithrombinChemistryHuman bloodAntiserumImmunofluorescenceBiochemistry

摘要: Abstract Associations between whole human platelets and plasma protease inhibitors were studied by direct immunofluorescence techniques. Tested conjugates of anti-human antisera to α 1 -antitrypsin, 2 -macroglobulin, -antichymotrypsin, inter-α-trypsin inhibitor, Cl inhibitor antithrombin III used. Only -antitrypsin found be associated with platelets. The biological role platelet-associated is discussed.

参考文章(16)
Gerard J. Arlaud, Angeline Reboul, Robert B. Sim, Maurice G. Colomb, Interaction of C1-inhibitor with the C1r and C1s subcomponents in human C1 Biochimica et Biophysica Acta. ,vol. 576, pp. 151- 162 ,(1979) , 10.1016/0005-2795(79)90494-X
R L Nachman, P C Harpel, Platelet alpha2-macroglobulin and alpha1-antitrypsin. Journal of Biological Chemistry. ,vol. 251, pp. 4514- 4520 ,(1976) , 10.1016/S0021-9258(17)33232-5
D.L. Ballantyne, A.D. Harper, G.A. Hawthorne, P. Nathan, R.J. Coburn, Circulating platelet levels in the rat during rejection of xenogeneic skin Thrombosis Research. ,vol. 4, pp. 177- 182 ,(1974) , 10.1016/0049-3848(74)90213-8
P Hilgard, The role of blood platelets in experimental metastases. British Journal of Cancer. ,vol. 28, pp. 429- 435 ,(1973) , 10.1038/BJC.1973.168
J. Murray, G. P. M. Crawford, D. Ogston, A. S. Douglas, Studies on an inhibitor of plasminogen activators in human platelets. British Journal of Haematology. ,vol. 26, pp. 661- 668 ,(1974) , 10.1111/J.1365-2141.1974.TB00509.X
G Nalli, G Cattaneo, G.D Malamani, I Majolino, P.M Fornasari, P Almasio, F Piovella, E Ascari, Immunofluorescent detection of α1-antitrypsin in platelets and megakaryocytes Thrombosis Research. ,vol. 10, pp. 613- 617 ,(1977) , 10.1016/0049-3848(77)90216-X
Fletcher B. Taylor, Hans J. Müller-Eberhard, Qualitative description of factors involved in the retraction and lysis of dilute whole blood clots and in the aggregation and retraction of platelets Journal of Clinical Investigation. ,vol. 49, pp. 2068- 2085 ,(1970) , 10.1172/JCI106425