Biochemical markers of bone turnover in seronegative spondylarthropathy: relationship to disease activity.
作者： A. G. MacDonald , G. Birkinshaw , B. Durham , R. C. Bucknall , W. D. Fraser
DOI: 10.1093/RHEUMATOLOGY/36.1.50
关键词: Bone resorption 、 Creatinine 、 Erythrocyte sedimentation rate 、 Resorption 、 Medicine 、 Acute-phase protein 、 Internal medicine 、 Endocrinology 、 Osteopenia 、 Procollagen peptidase 、 Bone remodeling
摘要: To investigate bone turnover in patients with seronegative spondylarthropathy, a formation marker, type 1 procollagen carboxy-terminal propeptide (P1CP), and resorption markers, the pyridinium cross-links of collagen [urinary free (f) PYR DPYR], were measured. The median f-PYR, f-DPYR P1CP (+/-interquartile range) 15.8 (6.00) nmol/mmol creatinine, 3.8 (2.2) creatinine 101.5 (38) micrograms/1, respectively. There was positive correlation between markers acute-phase reactants such as C-reactive protein (r = 0.42 for PYR, r DPYR, P < 0.05), negative observed erythrocyte sedimentation rate -0.64, 0.05). In subgroup an elevated CRP concentration, concentration DPYR significantly increased (f-PYR 25.7 vs 6.6 3.8, 0.01 0.05 f-DPYR). This study suggests than elevation response spondylarthropathy is associated tendency reduction markers. may represent uncoupling resorption, leading to loss patients.
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