Inflammatory signaling in macrophages: transitions from acute to tolerant and alternative activation states.
作者： Lionel B. Ivashkiv
关键词: Regulation of gene expression 、 Inflammation 、 MAPK/ERK pathway 、 Immune tolerance 、 Cell biology 、 Gene expression 、 Signal transduction 、 Biology 、 Chromatin 、 Interferon regulatory factors
摘要: Acute inflammatory activation of macrophages by Toll-like and related receptors is characterized transient MAPK-, NF-κB- IRF-mediated signaling pathways expression pro-inflammatory genes. This state inherently unstable often transitions into a 'tolerance' diminished signaling, repressive chromatin modifications, an alternative gene program. Viewpoint describes epigenetic mechanisms associated with transition to tolerant states, which are proposed correspond states programmed the original stimuli.
sci-hub.se 参考文章(40)
Diana C. Hargreaves, Tiffany Horng, Ruslan Medzhitov, Control of Inducible Gene Expression by Signal-Dependent Transcriptional Elongation Cell. ,vol. 138, pp. 129- 145 ,(2009) , 10.1016/J.CELL.2009.05.047
Edwige Nicodeme, Kate L. Jeffrey, Uwe Schaefer, Soren Beinke, Scott Dewell, Chun-wa Chung, Rohit Chandwani, Ivan Marazzi, Paul Wilson, Hervé Coste, Julia White, Jorge Kirilovsky, Charles M. Rice, Jose M. Lora, Rab K. Prinjha, Kevin Lee, Alexander Tarakhovsky, Suppression of inflammation by a synthetic histone mimic Nature. ,vol. 468, pp. 1119- 1123 ,(2010) , 10.1038/NATURE09589
Subhra K. Biswas, Eduardo Lopez-Collazo, Endotoxin tolerance: new mechanisms, molecules and clinical significance Trends in Immunology. ,vol. 30, pp. 475- 487 ,(2009) , 10.1016/J.IT.2009.07.009
Christopher K. Glass, Kaoru Saijo, Nuclear receptor transrepression pathways that regulate inflammation in macrophages and T cells Nature Reviews Immunology. ,vol. 10, pp. 365- 376 ,(2010) , 10.1038/NRI2748
Francesca De Santa, Maria Grazia Totaro, Elena Prosperini, Samuele Notarbartolo, Giuseppe Testa, Gioacchino Natoli, The Histone H3 Lysine-27 Demethylase Jmjd3 Links Inflammation to Inhibition of Polycomb-Mediated Gene Silencing Cell. ,vol. 130, pp. 1083- 1094 ,(2007) , 10.1016/J.CELL.2007.08.019
G. Natoli, S. Ghisletti, I. Barozzi, The genomic landscapes of inflammation Genes & Development. ,vol. 25, pp. 101- 106 ,(2011) , 10.1101/GAD.2018811
Foo Y. Liew, Damo Xu, Elizabeth K. Brint, Luke A. J. O'Neill, Negative regulation of Toll-like receptor-mediated immune responses Nature Reviews Immunology. ,vol. 5, pp. 446- 458 ,(2005) , 10.1038/NRI1630
Stephen T. Smale, Selective transcription in response to an inflammatory stimulus. Cell. ,vol. 140, pp. 833- 844 ,(2010) , 10.1016/J.CELL.2010.01.037
Lu Wang, Rachael A Gordon, Linda Huynh, Xiaodi Su, Kyung-Hyun Park Min, Jiahuai Han, J Simon Arthur, George D Kalliolias, Lionel B Ivashkiv, None, Indirect Inhibition of Toll-like Receptor and Type I Interferon Responses by ITAM-Coupled Receptors and Integrins Immunity. ,vol. 32, pp. 518- 530 ,(2010) , 10.1016/J.IMMUNI.2010.03.014
Muhammad M Alam, Luke A O'Neill, None, MicroRNAs and the resolution phase of inflammation in macrophages European Journal of Immunology. ,vol. 41, pp. 2482- 2485 ,(2011) , 10.1002/EJI.201141740