The genomic landscapes of inflammation
作者： G. Natoli , S. Ghisletti , I. Barozzi
DOI: 10.1101/GAD.2018811
关键词: Immunology 、 Biology 、 Regulation of gene expression 、 Transcription factor 、 TCF4 、 Inflammation 、 Enhancer 、 Cell type 、 Interferon regulatory factors 、 Response element
摘要: Inflammation involves the activation of a highly coordinated gene expression program that is specific for initial stimulus and occurs in different manner bystander parenchymal cells professional immune system recruited to inflamed site. Recent data demonstrate developmental transcription factors like macrophage fate-determining Pu.1 set stage activity ubiquitous activated by inflammatory stimuli, NF-kB, AP-1, interferon regulatory (IRFs). The intersection lineage-determining stimulus-activated at enhancers explains cell type specificity responses.
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