The functional repertoires of metazoan genomes

作者: Chris P. Ponting

DOI: 10.1038/NRG2413

关键词:

摘要: Metazoan genomes are being sequenced at an increasingly rapid rate. For each new genome, the number of protein-coding genes it encodes and amount functional DNA contains known only inaccurately. Nevertheless, there have been considerable recent advances in identifying non-coding sequences that remained constrained diverse species. However, these approaches struggle to pinpoint genomic some species but absent or not others. Yet is here, encoded lineage-specific sequence, we expect physiological differences between be most concentrated.

参考文章(94)
Michael Lynch, John S. Conery, The evolutionary demography of duplicate genes Journal of Structural and Functional Genomics. ,vol. 3, pp. 35- 44 ,(2003) , 10.1023/A:1022696612931
Michael Lynch, Bruce Walsh, The Origins of Genome Architecture ,(2007)
Hui Huang, Eitan E Winter, Huajun Wang, Keith G Weinstock, Heming Xing, Leo Goodstadt, Peter D Stenson, David N Cooper, Douglas Smith, M Mar Albà, Chris P Ponting, Kim Fechtel, Evolutionary conservation and selection of human disease gene orthologs in the rat and mouse genomes. Genome Biology. ,vol. 5, pp. 1- 15 ,(2004) , 10.1186/GB-2004-5-7-R47
Chimpanzee Sequencing and Analysis Consortium Waterson Robert H. waterston@ gs. washington. edu Lander Eric S. lander@ broad. mit. edu Wilson Richard K. rwilson@ watson. wustl. edu, None, Initial sequence of the chimpanzee genome and comparison with the human genome Nature. ,vol. 437, pp. 69- 87 ,(2005) , 10.1038/NATURE04072
Zoë Birtle, Leo Goodstadt, Chris Ponting, Duplication and positive selection among hominin-specific PRAME genes BMC Genomics. ,vol. 6, pp. 120- 120 ,(2005) , 10.1186/1471-2164-6-120
Gerton Lunter, Chris P Ponting, Jotun Hein, Genome-wide identification of human functional DNA using a neutral indel model. PLOS Computational Biology. ,vol. 2, ,(2005) , 10.1371/JOURNAL.PCBI.0020005
Michael R. Brent, Steady progress and recent breakthroughs in the accuracy of automated genome annotation Nature Reviews Genetics. ,vol. 9, pp. 62- 73 ,(2008) , 10.1038/NRG2220
Laurence D. Hurst, Csaba Pál, Martin J. Lercher, The evolutionary dynamics of eukaryotic gene order Nature Reviews Genetics. ,vol. 5, pp. 299- 310 ,(2004) , 10.1038/NRG1319
Christina M Laukaitis, Andreas Heger, Tyler D Blakley, Pavel Munclinger, Chris P Ponting, Robert C Karn, Rapid bursts of androgen-binding protein (Abp) gene duplication occurred independently in diverse mammals BMC Evolutionary Biology. ,vol. 8, pp. 46- 46 ,(2008) , 10.1186/1471-2148-8-46