Relatively Small Contribution of Methylation and Genomic Copy Number Aberration to the Aberrant Expression of Inflammation-Related Genes in HBV-Related Hepatocellular Carcinoma
作者： Dianke Yu , Guosheng Zhang , Xudong Huang , Chen Wu , Wen Tan
DOI: 10.1371/JOURNAL.PONE.0126836
关键词:
摘要: Background It is well known that chronic inflammation plays a pivotal role in the development of hepatitis B virus (HBV) related hepatocellular carcinoma (HCC). However, causes behind aberrant expression inflammation-related genes occurred HCC remain unclear. Methods We performed array-based analyses to comprehensively investigate contributions DNA methylation and somatic copy number aberration (SCNA) 1,027 30 HCCs paired non-tumor tissues. The results were validated public datasets an additional sample set 47 tissues. Results identified 252 differentially expressed, 125 aberrantly methylated 287 changed genes. Despite reasonable statistical power, among them, only 11 56 whose was associated with or SCNA, respectively. SCNA together contributed less than 30% genes. Conclusion These suggest molecular mechanisms other might play major regulation gene HBV-related HCCs.
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