Establishment of Experimental Murine Peritonitis Model with Hog Gastric Mucin for Carbapenem-Resistant Gram-Negative Bacteria
作者： Jung Yeon Park , Chulmin Park , Hye-Sun Chun , Ji-Hyun Byun , Sung-Yeon Cho
关键词: Escherichia coli 、 Mucin 、 Bacteria 、 Gram-negative bacteria 、 Microbiology 、 Pseudomonas aeruginosa 、 Peritonitis 、 Medicine 、 Acinetobacter baumannii 、 Klebsiella pneumoniae
摘要: Animal models are essential to studies of infectious diseases. The use mice test bacterial infection has been extensively reported. However, methods applied clinical isolates, particularly for carbapenem-resistant bacteria, must be tailored according the and bacteria used. In this study, we infected 6-week-old female BALB/c intraperitoneally with different strains resistant plus 3% hog gastric mucin. This method was found efficient readily applicable investigation carbapenem-resisant Gram-negative pathogens (e.g., Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii) detected in Korea.
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