Piscidin is Highly Active against Carbapenem-Resistant Acinetobacter baumannii and NDM-1-Producing Klebsiella pneumonia in a Systemic Septicaemia Infection Mouse Model
作者： Chieh-Yu Pan , Jian-Chyi Chen , Te-Li Chen , Jen-Leih Wu , Cho-Fat Hui
DOI: 10.3390/MD13042287
关键词:
摘要: This study was designed to investigate the antimicrobial activity of two synthetic peptides from an aquatic organism, tilapia piscidin 3 (TP3) and 4 (TP4), in vitro a murine sepsis model, as compared with ampicillin, tigecycline, imipenem. Mice were infected (NDM-1)-producing K. pneumonia multi-drug resistant Acinetobacter baumannii, subsequently treated TP3, TP4, or antibiotics for different periods time (up 168 h). Mouse survival bacterial colony forming units (CFU) various organs measured after each treatment. Toxicity determined based on observation behavior measurement biochemical parameters. TP3 TP4 exhibited strong against A. baumannii vitro. Administration (150 μg/mouse) (50 30 min infection significantly increased mice. more effective than tigecycline at reducing CFU counts several organs. shown be non-toxic, did not affect mouse behavior. are able potentiate anti-Acinetobacter anti-Klebsiella drug activity, reduce load, prevent resistance, indicating their potential use combating multidrug-resistant bacteria.
mdpi.com
core.ac.uk
doaj.org
cabdirect.org参考文章(51)
AE Sirvent, J Borrás-Blasco, F Amoros, S Padilla, J Solavera, R Enríquez, A Navarro-Ruiz, Imipenem-induced Clostridium difficile diarrhea in a patient with chronic renal failure. Saudi Journal of Kidney Diseases and Transplantation. ,vol. 22, pp. 541- 543 ,(2011)
Mary Jane. Ferraro, Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically NCCLS. ,(2000)
Umaporn Silphaduang, Edward J. Noga, Peptide antibiotics in mast cells of fish Nature. ,vol. 414, pp. 268- 269 ,(2001) , 10.1038/35104690
Karen Bush, Mark Macielag, Michele Weidner-Wells, Taking inventory: antibacterial agents currently at or beyond phase 1. Current Opinion in Microbiology. ,vol. 7, pp. 466- 476 ,(2004) , 10.1016/J.MIB.2004.08.013
Abdolaziz Rastegar Lari, Leila Azimi, Mohammad Rahbar, Fatemeh Fallah, Reza Alaghehbandan, Phenotypic detection of Klebsiella pneumoniae carbapenemase among burns patients: First report from Iran Burns. ,vol. 39, pp. 174- 176 ,(2013) , 10.1016/J.BURNS.2012.02.025
Geneviève LeBel, Fanny Piché, Michel Frenette, Marcelo Gottschalk, Daniel Grenier, Antimicrobial activity of nisin against the swine pathogen Streptococcus suis and its synergistic interaction with antibiotics. Peptides. ,vol. 50, pp. 19- 23 ,(2013) , 10.1016/J.PEPTIDES.2013.09.014
Y. Jerold Gordon, Eric G. Romanowski, Alison M. McDermott, A Review of Antimicrobial Peptides and Their Therapeutic Potential as Anti-Infective Drugs Current Eye Research. ,vol. 30, pp. 505- 515 ,(2005) , 10.1080/02713680590968637
Mei-Hui Lee, Te-Li Chen, Yi-Tzu Lee, Lei Huang, Shu-Chen Kuo, Kwok-Woon Yu, Po-Ren Hsueh, Horng-Yunn Dou, Ih-Jen Su, Chang-Phone Fung, None, Dissemination of multidrug-resistant Acinetobacter baumannii carrying BlaOxA-23 from hospitals in central Taiwan. Journal of Microbiology Immunology and Infection. ,vol. 46, pp. 419- 424 ,(2013) , 10.1016/J.JMII.2012.08.006
Iván Mulero, Edward J. Noga, José Meseguer, Alfonsa García-Ayala, Victoriano Mulero, The antimicrobial peptides piscidins are stored in the granules of professional phagocytic granulocytes of fish and are delivered to the bacteria-containing phagosome upon phagocytosis Developmental & Comparative Immunology. ,vol. 32, pp. 1531- 1538 ,(2008) , 10.1016/J.DCI.2008.05.015
Su-Fang Niu, Yuan Jin, Xin Xu, Ying Qiao, Yang Wu, Yong Mao, Yong-Quan Su, Jun Wang, Characterization of a novel piscidin-like antimicrobial peptide from Pseudosciaena crocea and its immune response to Cryptocaryon irritans Fish & Shellfish Immunology. ,vol. 35, pp. 513- 524 ,(2013) , 10.1016/J.FSI.2013.05.007