Attacking the HIV Reservoir from the Immune and Viral Perspective

摘要: Upon HIV infection, a subset of latently infected cells carrying transcriptionally inactive integrated proviral DNA (the HIV-1 reservoir) is rapidly established. These are the main force behind persistence under highly active antiretroviral therapy (HAART), which only impacts on actively replicating viruses and it therefore unable to eradicate infection. However, case Timothy Brown, also known as Berlin patient, demonstrates that eradication possible, recent data support idea latency may be reverted in vivo, suggesting possible perturb reservoir. This achieved by implementing both pharmacological immunological strategies reactivate from cells. Nevertheless, reactivation might not sufficient virus. Reinforcing HIV-1-specific immune responses blocking potential new events viral replication will probably help reaching final goal or alternative objective functional cure for HIV-1.