7SK small nuclear ribonucleoprotein complex is recruited to the HIV‐1 promoter via short viral transcripts
作者： Taketoshi Mizutani , Aya Ishizaka , Yutaka Suzuki , Hideo Iba
DOI: 10.1016/J.FEBSLET.2014.01.067
关键词:
摘要: In this study, we demonstrate that the 7SK small nuclear ribonucleoprotein (snRNP) complex is recruited to HIV-1 promoter via newly-synthesized nascent transcripts (short transcripts) in an hnRNP A1-dependent manner and negatively regulates viral transcript elongation. Our deep-sequence analysis showed these short were mainly arrested at approximately +50 +70 nucleotides from transcriptional start site U1 cells, latent model. TNF-α treatment promptly disrupted snRNP on elongated increased. This report provides insight into how absence of Tat.
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