Human immunodeficiency virus type 1 (HIV-1) induces the cytoplasmic retention of heterogeneous nuclear ribonucleoprotein A1 by disrupting nuclear import: implications for HIV-1 gene expression.
作者： Anne Monette , Lara Ajamian , Marcelo López-Lastra , Andrew J. Mouland
关键词:
摘要: Human immunodeficiency virus type 1 (HIV-1) co-opts host proteins and cellular machineries to its advantage at every step of the replication cycle. Here we show that HIV-1 enhances heterogeneous nuclear ribonucleoprotein (hnRNP) A1 expression promotes relocalization hnRNP cytoplasm. The latter was dependent on export unspliced viral genomic RNA (vRNA) alterations in abundance localization FG-repeat pore glycoprotein p62. vRNA remain colocalized cytoplasm supporting a post-nuclear function during late stages replication. Consistently, acts as an internal ribosomal entry site trans-acting factor up-regulating ribosome site-mediated translation initiation vRNA. up-regulation cytoplasmic retention by would ensure abundant structural cells infected with HIV-1.
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