Upregulated expression of LncRNA nicotinamide nucleotide transhydrogenase antisense RNA 1 is correlated with unfavorable clinical outcomes in cancers

摘要: The nicotinamide nucleotide transhydrogenase antisense RNA 1 (NNT-AS1) is a long non-coding aberrantly expressed in human malignancies. We aimed to analyze available data evaluate the correlation between NNT-AS1 expression and cancer prognosis. Literature retrieval was performed by systematic searching related databases from inception April 2, 2020. Studies regarding expression, survival outcomes clinical characteristics of patients were collected pooled calculate hazard ratios (HRs) or odds (ORs) with 95% confidence intervals (95% CIs). Ten studies comprising 699 included, all which conducted China according literature selection criteria. Overexpression had significant association unfavorable overall (OS) (HR = 2.08, CI: 1.84–2.36, P < 0.001). Stratified analysis showed that tumor type, sample size, follow-up months, approach did not change predictive value on OS. Furthermore, elevated level distant metastasis (DM) (OR = 2.45, 1.39–4.30), lymph node (LNM) (OR = 3.92, 1.35–11.41), TNM stage (OR = 4.25, 1.71–10.56), vascular invasion (OR = 3.98, 2.06–7.71), but associated age gender. TCGA dataset further consistently poor OS disease-free survival. High clinicopathologic characteristics. However, large-cohort geographical are still needed validate prognostic cancers.