Association between smoking habits and the first-time appearance of atrial fibrillation in Japanese patients: Evidence from the Shinken Database

摘要: Abstract Background We previously reported a cross-sectional analysis regarding the relationship between smoking and atrial fibrillation (AF) in single hospital-based cohort with Japanese patients, but effect of cessation and/or total tobacco consumption were unclear. Methods results used data from Shinken Database 2004–2011 (men/women, n = 10,714/6803, respectively), which included all new patients attending Cardiovascular Institute June 2004 March 2012. After excluding those diagnosed AF (n = 2296), 15,221 n = 9016/6205) analyzed. During follow-up period 2.0 ± 2.1 years (range 0.0–8.1), incidence rates smokers non-smokers 9.0 5.0 per 1000 patient-years, respectively. In adjusted models Cox regression analysis, independently associated [hazard ratio (HR) 1.47, 95% confidence interval (CI) 1.09–2.00]. Also, current (HR 1.81, CI 1.17–2.79) Brinkman index ≥800 1.69, 1.05–2.70) AF. However, smokers, HRs not different by (Brinkman Conclusions Smoking was first-appearance sinus rhythm, especially when continued their habit. who smoking, difference observed, suggesting significance for preventing Our are limited because nature relatively short observation period.