In Vivo and in Vitro Models of Demyelinating Disease

摘要: Murine coronaviruses, including MHV-A59, MHV-3, and JHM, have a neurotropic potential in rodents causing either an acute fatal encephalitis or paralytic disease (Bailey et al., 1949; Lampert 1973; Le Provost 1975; Hirano 1980; Knobler al, 1981b). Central nervous system (CNS) infection of mice may result from intracerebral (IC) intraperitoneal (IP) inoculation number these which tropisms for various CNS cells glia neurons (Virelizier Fleury 1981a). By contrast, rats overt symptoms are associated exclusively with JHM virus (JHMV) (Hirano Sorensen 1980). An IC MHV-3 into replication without our unpublished data), implying that this strain replicates not critical function, at least as judged by clinical criteria. Although the rat appears to be transitory, JHMV RNA can identified some asymptomatic animals several months post-inoculation (Sorensen 1984). It remains established whether, under circumstances, persists low titers infectious entity enters truly latent state.