Mitogen-Activated Protein Kinase Signaling Pathway in Cutaneous Melanoma: An Updated Review

摘要: The mitogen-activated protein kinase (MAPK) signaling pathway is a cascade of kinases that act in sequential and predominantly linear fashion, albeit displaying some cross talk with other cascades. Mutations proteins integral to the MAPK are present more than 50% cutaneous melanomas. most frequently mutated v-raf murine sarcoma viral oncogene homolog B (BRAF), followed by neuroblastoma Ras (NRAS). Recently, development targeted drugs for treatment BRAF-mutant melanoma has led widespread implementation molecular assays detection specific BRAF mutations. There have been attempts standardize testing mutations, but this not achieved so far. Here we provide an updated review on role pathogenesis melanoma, focusing several different mutations their diagnostic therapeutic implications.