作者: Kenneth H. Wolfe
DOI: 10.1371/JOURNAL.PBIO.1002221
关键词: Phylogenetics 、 Genome 、 Biology 、 Paleogenetics 、 Saccharomyces cerevisiae 、 Gene 、 Genomics 、 Genetics 、 Evolutionary biology 、 Lineage (evolution) 、 Gene duplication
摘要: Whole-genome duplications (WGDs) are rare evolutionary events with profound consequences. They double an organism's genetic content, immediately creating a reproductive barrier between it and its ancestors providing raw material for the divergence of gene functions paralogs. Almost all eukaryotic genome sequences bear evidence ancient WGDs, but causes these timing intermediate steps have been difficult to discern. One best-characterized WGDs occurred in lineage leading baker's yeast Saccharomyces cerevisiae. Marcet-Houben Gabaldon now show that, rather than simply doubling DNA single ancestor, WGD likely involved mating two different ancestral species followed by restore fertility.