Endocardial Notch Signaling in Cardiac Development and Disease
作者： Guillermo Luxán , Gaetano D’Amato , Donal MacGrogan , José Luis de la Pompa
DOI: 10.1161/CIRCRESAHA.115.305350
关键词: Signal transduction 、 Internal medicine 、 Heart disease 、 Cell fate determination 、 Cell biology 、 Regeneration (biology) 、 Endocardium 、 Cardiology 、 Notch signaling pathway 、 Biology 、 Morphogenesis 、 Heart morphogenesis
摘要: The Notch signaling pathway is an ancient and highly conserved that controls cell fate specification tissue patterning in the embryo adult. Region-specific endocardial activity regulates heart morphogenesis through interaction with multiple myocardial-, epicardial-, neural crest-derived signals. Mutations NOTCH elements cause congenital disease humans mice, demonstrating its essential role cardiac development. Studies model systems have provided mechanistic understanding of function development, disease, regeneration. patterns embryonic endocardium into prospective territories for valve chamber formation, later processes leading to outflow tract ventricular trabeculae compaction. Alterations result structural malformations can lead neonate adult heart.
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