Bmp2 instructs cardiac progenitors to form the heart-valve-inducing field.
作者： José Rivera-Feliciano , Clifford J. Tabin
DOI: 10.1016/J.YDBIO.2006.03.043
关键词:
摘要: A hallmark of heart-valve development is the swelling and deposition extracellular matrix in region. Only myocardium overlying this region can signal to underlying endothelium cause it lose cell–cell contacts, delaminate, invade space abutting endocardium form endocardial cushions (EC) a process known as epithelial mesenchymal transformation (EMT). The expresses bone morphogenetic protein-2 (Bmp2) coincident with valve mesenchyme. BMPs belong transforming growth factor beta superfamily (TGF-β) play wide variety roles during development. We show that conditional ablation Bmp2 cardiac progenitors results cell fate changes which adopts identity differentiated chamber myocardium. Moreover, Bmp2-deficient hearts fail induce production at heart-valve-forming region, resulting inability swell impairing ECs. Furthermore, collagen invasion assays, mutant incapable undergoing EMT, addition BMP2 protein heart explants rescues phenotype. Our demonstrate both necessary sufficient specify field progenitor cells heart-valve-inducing amid developing atria ventricles.
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