B Cell Receptor- and β2-Adrenergic Receptor-Induced Regulation of B7-2 (CD86) Expression in B Cells

摘要: The costimulatory molecule B7-2 (CD86) is expressed on the surface of APCs, including B cells. Considering importance in regulating both T and cell function, it may be important to understand regulatory mechanisms governing its expression. We report this study that stimulation receptor (BCR) and/or a neurotransmitter receptor, β 2 -adrenergic (β AR), cooperate regulate cell-associated expression vitro vivo. AR further enhanced level BCR-induced cells potentially via protein tyrosine kinase-, kinase A-, C-, mitogen-activated kinase-dependent mechanisms. Importantly, BCR stimulation, but not histone hyperacetylation DNA hypomethylation alone, increased by increasing mRNA stability, NF-κB nuclear binding, NF-κB-dependent gene transcription. Thus, provides additional insight into signaling intermediates molecular which