Incomplete Infarct and Delayed Neuronal Death After Transient Middle Cerebral Artery Occlusion in Rats
作者： Julio H. Garcia , Kai-Feng Liu , Zhu-Rong Ye , Jorge A. Gutierrez
DOI: 10.1161/01.STR.28.11.2303
关键词: Vascular disease 、 Necrosis 、 Internal medicine 、 Ischemia 、 Cardiology 、 Central nervous system disease 、 Medicine 、 Middle cerebral artery 、 Pathology 、 Artery 、 Cerebral arteries 、 Cerebral infarction
摘要: Background and Purpose The clinical syndrome of transient ischemic attacks is accompanied in a significant percentage patients by brain lesions or neuroimaging abnormalities whose structural counterparts have not been defined. objective this study was to analyze, an experimental model short-term (<25 minutes) focal ischemia long-term (≤28 days) reperfusion, the extent nature affecting neurons glia located within territory transiently occluded artery. Methods Adult Wistar rats (n=121) had origin one middle cerebral artery (MCA) with nylon monofilament for periods 10 25 minutes. Experiments MCA occlusion were terminated at variable ranging from 1 day 4 weeks. Control experiments consisted (1) without reperfusion (n=7) lasting 7 14 days (2) sham operations (n=2) followed 1- 4-day survival. After situ fixation, specimens serially sectioned subje...
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