Relative iron "overload" in offspring of patients with type 2 diabetes mellitus: a new component in the conundrum of insulin resistance syndrome?

摘要: There are a few reports suggesting that subtle disturbances of iron metabolism frequently found in patients with type 2 diabetes (DM2), but it is not known if these precede or accompany the diabetic state. We investigated serum indices 41 offspring DM2 parents (group I) normal glucose tolerance, and 49 whose had no history were matched for sex, age, body mass index (BMI), waist to hip ratio (WHR) blood pressure II). Serum iron, ferritin, total binding capacity (TIBC), transferrin saturation, triglycerides, cholesterol, Apo-B, high density lipoprotein (HDL) insulin values during an oral tolerance test measured. Insulin resistance was assessed using homeostasis model assessment (HOMA - Insuline resistence index-IRI). In comparison controls II), subjects higher fasting triglycerides (mean +/- SD 2.25+/-2.08 vs. 1.6+/-0.8 mmol/L, p<0,05), lower HDL cholesterol (0.96 0.2 1.1 p<0.001), (5.5 5.1 0.8 p < 0.05), apo-B-lipoprotein (133.2+/-34.3 125.5+/-30.5 mg/dl, p<0.05), LDL-C (3.7 3.2 0.6 mmol/L), gamma-GT (28+/-10 17+/-5.6 iu/L, p<0.01) Area Under Curve (204.7+/-140.8 v. 153.1 63.0 microU/ml, p<0.05) HOMA-IRI (2.84+/-1.39 1.67+/-0.77, ferritin concentrations (98.3+/-57.7 62.0+/-41.1 ng/ml, p<0.01), concentration (20.2+/-6.0 micromol/L 14.5+/-4.3, p<0.001) saturation (31.3+/-8.4 22.6+/-7.3, p<0.0001). By single linear analysis parents, there positive correlation IRI (r=0.400, fibrinogen (r=0.377, p=0.025) (r=0.344, p=0.041), negative TIBC (r=-0.477, 0.0001), while stepwise multiple regression analysis, showed (b=0.64, t=3.746, (b=0.37, t=2.619, (b=0.20, t=1.827, p=0.05). No IRI, any above parameters seen parents. logistic characterizing (OR 14.9 CI 2.4-91.0) 44.2 6.9-281), 6.1 1.01-37.0 29.6 5.0-174). conclusion, data indicate load, significantly increased unaffected tolerance. Furthermore, related resistance. Hence, relative "overload" diabetics present along might worsen hepatic insensitivity already patients.