Study of common quantification methods of amide proton transfer magnetic resonance imaging for ischemic stroke detection

摘要: Purpose To assess the correlation and differences between common amide proton transfer (APT) quantification methods in diagnosis of ischemic stroke. Methods Five APT methods, including asymmetry analysis its variants as well two Lorentzian model-based were applied to data acquired from six rats that underwent middle cerebral artery occlusion scanned at 9.4T. Diffusion perfusion-weighted images, water relaxation time maps also study relationship these conventional imaging modalities with different methods. Results The area estimates had varying sizes (Jaccard index: 0.544 ≤ J 0.971) correlations their distributions (Pearson coefficient: 0.104 r 0.995), revealing discrepancies quantified areas. produced highest contrast-to-noise ratios (CNRs; 1.427 CNR 2.002), but generated areas comparable size blood flow (CBF) deficit areas; smaller than CBF larger apparent diffusion coefficient areas, though having lower CNRs (0.561 1.083). Conclusion There is a need further investigate accuracy each method pathophysiology using scale multi-imaging modality multi-time-point clinical study. Future studies should include magnetization ratio results alongside findings facilitate comparison centers published literature.