Additive Action of Two or More Solutes on Lipid Membranes

摘要: A wide variety of biological processes, pharmaceutical applications, and technical procedures is based on the combined action two or more soluble compounds to perturb, permeabilize, lyse membranes. Here we present a general model describing additive solutes properties membranes micelles. The onset completion membrane solubilization induced by surfactants (lauryl maltoside, with nonyl octyl glucoside, CHAPS, respectively) are very well described our basis their individual partition coefficients, cmc's, critical mole ratios R e sat sol as detected isothermal titration calorimetry. This suggests that thermodynamic phase transition governed single parameter (e.g., spontaneous curvature) in spite complexity structural changes. Such surfactant mixtures show unique features such nonlinear boundaries concentration-dependent effective coefficients. Other phenomena leakage predicted obey if act via same mechanism toroidal pore formation) but deviate from case independent, synergistic, antagonistic action.