A metabolic system-wide characterisation of the pig: a model for human physiology

摘要: The pig is a single-stomached omnivorous mammal and an important model of human disease nutrition. As such, it necessary to establish metabolic framework from which pathology-based variation can be compared. Here, combination one two-dimensional 1H 13C nuclear magnetic resonance spectroscopy (NMR) high-resolution magic angle spinning (HR-MAS) NMR was used provide systems overview porcine metabolism via characterisation the urine, serum, liver kidney metabolomes. metabolites observed in each these biological compartments were found qualitatively comparable signature same matrices humans rodents. data modelled using principal components analysis Venn diagram mapping. Urine represented most metabolically distinct compartment studied, with relatively greater number detectable present, many are implicated gut-microbial co-metabolic processes. major inter-species differences phase II conjugation extra-genomic metabolites; conjugate p-cresol, gut microbial metabolite tyrosine, glucuronide rather than sulfate as seen man. These observations note when considering translatability experimental derived models.