Matrine: A review of its pharmacology, pharmacokinetics, toxicity, clinical application and preparation researches.

作者: Xia Li , Ziwei Tang , Li Wen , Cen Jiang , Quansheng Feng

DOI: 10.1016/J.JEP.2020.113682

关键词: DetoxificationStructure modificationSophora flavescensToxicityClinical PracticeMatrinePharmacologyPharmacokineticsMedicineBiological property

摘要: Ethnopharmacological relevance “Dogel ebs” was known as Sophora flavescens Ait., which has been widely utilized in the clinical practice of traditional Chinese Mongolian herbal medicine for thousands of years. Shen Nong's Materia Medica (Shen Nong Ben Cao Jing in Chinese pinyin) recorded that it is bitter in taste and cold in nature with the effect of clearing heat and eliminating dampness, insecticide, diuresis. Due to its extensive application in the fields of ethnopharmacological utilization, the pharmaceutical researches of Sophora …

参考文章(186)
Fanhua Meng, Jianhui Wang, Fuxiang Ding, Yunliang Xie, Yingjie Zhang, Jie Zhu, Neuroprotective effect of matrine on MPTP-induced Parkinson's disease and on Nrf2 expression. Oncology Letters. ,vol. 13, pp. 296- 300 ,(2017) , 10.3892/OL.2016.5383
Xiao-Hua Cai, Hui Guo, Bing Xie, Structural Modifications of Matrine-Type Alkaloids Mini-reviews in Medicinal Chemistry. ,vol. 18, pp. 730- 744 ,(2016) , 10.2174/1389557516666161104150334
Quan-Cheng Kan, Hui-Jun Zhang, Yuan Zhang, Xing Li, Yu-Ming Xu, Rodolfo Thome, Ming-Liang Zhang, Nan Liu, Yao-Juan Chu, Guang-Xian Zhang, Lin Zhu, Erratum to: Matrine Treatment Blocks NogoA-Induced Neural Inhibitory Signaling Pathway in Ongoing Experimental Autoimmune Encephalomyelitis. Molecular Neurobiology. ,vol. 54, pp. 8404- 8418 ,(2017) , 10.1007/S12035-017-0410-0
Junqing Wu, Gang Hu, Yuqing Dong, Ruye Ma, Zhijie Yu, Songfu Jiang, Yixiang Han, Kang Yu, Shenghui Zhang, Matrine induces Akt/mTOR signalling inhibition-mediated autophagy and apoptosis in acute myeloid leukaemia cells. Journal of Cellular and Molecular Medicine. ,vol. 21, pp. 1171- 1181 ,(2017) , 10.1111/JCMM.13049
Yu-Bo Zhang, Xiao-Li Zhang, Neng-Hua Chen, Zhong-Nan Wu, Wen-Cai Ye, Yao-Lan Li, Guo-Cai Wang, Four Matrine-Based Alkaloids with Antiviral Activities against HBV from the Seeds of Sophora alopecuroides. Organic Letters. ,vol. 19, pp. 424- 427 ,(2017) , 10.1021/ACS.ORGLETT.6B03685
Liping Wang, Jinyao Lu, Wei Sun, Yingmin Gu, Chaochao Zhang, Ruomin Jin, Lingyong Li, Zean Zhang, Xuesong Tian, Hepatotoxicity induced by radix Sophorae tonkinensis in mice and increased serum cholinesterase as a potential supplemental biomarker for liver injury Experimental and Toxicologic Pathology. ,vol. 69, pp. 193- 202 ,(2017) , 10.1016/J.ETP.2017.01.003
Hyun-ju Lee, Sun-young Lee, Daehyuk Jang, Sun-Yong Chung, Insop Shim, None, Sedative Effect of Sophora flavescens and Matrine. Biomolecules & Therapeutics. ,vol. 25, pp. 390- 395 ,(2017) , 10.4062/BIOMOLTHER.2016.156
Yaojie Niu, Qiumei Dong, Rongheng Li, Matrine regulates Th1/Th2 cytokine responses in rheumatoid arthritis by attenuating the NF-κB signaling Cell Biology International. ,vol. 41, pp. 611- 621 ,(2017) , 10.1002/CBIN.10763
Zhongwei Liu, Yong Zhang, Zhiguo Tang, Jing Xu, Meijuan Ma, Shuo Pan, Chuan Qiu, Gongchang Guan, Junkui Wang, Matrine attenuates cardiac fibrosis by affecting ATF6 signaling pathway in diabetic cardiomyopathy European Journal of Pharmacology. ,vol. 804, pp. 21- 30 ,(2017) , 10.1016/J.EJPHAR.2017.03.061