Structural Modifications of Matrine-Type Alkaloids

摘要: Matrine-type alkaloids belong to quinolizidine analogues from Sophora flavescens Ait, subprostrata and alopecuroides L. possess numerous therapeutic properties have attracted continuous attention over the past few decades. In order improve activities amplify their applicants, many matrine-type derivatives synthesized evaluated for biological in recent years. These structural modifications resulted stronger improvement of pharmacokinetic properties. The structure activity relation studies based on matrine- type semi-synthetic immensely contributed understanding mechanism actions molecular targets. This review mainly summarizes progress alteration C-13 or C-14 position, opening D ring, fusing ring simplification.