Usefulness of DNA quantification in diagnosis of hypertrophic cardiomyopathies: A preliminary study

摘要: Hypertrophic cardiomyopathies (HCM) are a frequent cause of sudden death in both young people and adults. Different can be distinguished according to the etiological agent and, although there morphological differences too, alterations quantity DNA cardiomyocytes may play an important role their pathogenesis evolution. To understand characteristics behaviour index hypertrophic cardiomyopathies, we have studied thirty cases (10 primaries or essential, 10 hypertensives toxic) compared results with those obtained for macroscopically normal hearts. The showed that different were statistically related age, heart weight ventricle thickness. hearts showing diploid index, hypertensive (CM) tetraploid toxic CM (1.1-1.9) essential (>2) aneuploid index. Statistically significant associations (p < 0.001) observed when values type CM, thickness ventricles weight. Therefore, think technique described great help differential diagnosis cardiomyopathies.