Cytometric analysis of ventricular myocyte nuclei in idiopathic dilated cardiomyopathy: a tool for evaluation of disease progression?

摘要: The progression of idiopathic dilated cardiomyopathy (ii) C) is governed by factors that remain obscure. disease pathway toward cell degeneration or death results in irreversible myocyte change including nuclear cytometric alterations which may be evaluable and ultimately correlated with other measures evolution. Using a novel image cytometry system, we analysed differences ventricular morphology DNA content distribution right left free wall myocardium septal from 11 normal 13 IDC human autopsy hearts. Nine morphological features nuclei differed significantly (P < 0.001) normal. These were used to establish classification matrix cytometry-based assessment allowed correct categorization concordance their respective pathological diagnosis (i.e. IDC) 71%, 81% 77% the time. Additionally, four photometric different 0.005) versus hearts ; as three discrete texture 0.001). Thus, spectrum seen have highly characteristic measurable morphologic, features. Our findings indicate potential value myocytes regards continuum suggest its applicability both clinical experimental studies.