Behavioral Effects of Liothyronine (L-T3) in Children with Attention Deficit Hyperactivity Disorder in the Presence and Absence of Resistance to Thyroid Hormone
作者： R.E. WEISS , M.A. STEIN , S. REFETOFF
关键词: Pediatrics 、 Randomized controlled trial 、 Thyroid 、 Psychiatry 、 Attention deficit hyperactivity disorder 、 Medicine 、 Liothyronine 、 Prospective cohort study 、 Hormone 、 Impulsivity 、 Crossover study
摘要: Evidence that the thyroid may play a role in pathogenesis of attention deficit hyperactivity disorder (ADHD) comes from observations 48% to 73% children with syndrome resistance hormone (RTH) have ADHD. Casual subjects RTH suggested treatment improve symptoms The aim this study was determine whether has beneficial effect on behavior RTH. A prospective, randomized, double-blinded, placebo-controlled, cross-over conducted evaluate rapid acting hormone, liothyronine (L-T3), 8 ADHD + RTH, and 9 normal function (ADHD Only). Parent teacher ratings (Conners scale) computerized continuous performance test (CPT) were used as objective measures hyperactivity, impulsivity. L-T3 had no Conners Hyperactivity Index 7 Only; it caused improvement deterioration 1 subject each. In contrast, rating 5 showed improvement, whereas 3 remained unchanged. associated increased commission errors Only decreased 4 ADHD, particularly those exhibit supraphysiological doses be reducing majority who do not or detrimental.
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