CCAAT/enhancer binding protein-mediated role of thyroid hormone in the developmental expression of the kidney androgen-regulated protein gene in proximal convoluted tubules.

摘要: The kidney androgen-regulated protein (KAP) gene is exclusively expressed in proximal tubules of mouse and the uterus pregnant females before they give birth. It displays an exquisite differential regulation expression by steroid thyroid hormones (THs) different tubule segments. Whereas pars recta (PR cells) responds to sexual hormones, convoluta (PCT represents a truly androgen-dependent compartment because occurs only presence androgens functional androgen receptors. Nevertheless, hypothyroidism models have indicated that TH might also contribute androgenic response PCT cells. In present study, we aimed determine molecular mechanisms ultimately control KAP these Using several genetically deficient pharmacologic hormonal treatments, determined GH modulate CCAAT/enhancer binding α β levels that, ...