Identification of the cis-acting elements and trans-acting factors that mediate cell-specific and thyroid hormone stimulation of growth hormone gene expression.
作者： HERBERT H. SAMUELS , ANA ARANDA , JUAN CASANOVA , RICHARD P. COPP , FRANCES FLUG
DOI: 10.1016/B978-0-12-571144-9.50007-7
关键词: Cell biology 、 Thyroid hormone receptor beta 、 Thyroid 、 Hormone receptor 、 Parathyroid hormone receptor 、 Thyroid hormone receptor alpha 、 Thyroid hormone receptor 、 Hormone response element 、 Internal medicine 、 Biology 、 PAX8 、 Endocrinology
摘要: Publisher Summary This chapter reviews the physical and biological properties of thyroid hormone receptors relationship receptor to avian erythroblastosis virus (AEV) v-erbA gene. The nuclear derived from studies using GHi GC cells are described in chapter. is related AEV—a defective leukemia retrovirus—induces sarcomas vivo induces transformation fibroblasts erythroblasts neoplastic phenotypes vitro. also which rat growth gene was used as a model identify cis-acting DNA sequences transacting regulatory proteins that essential for cell-specific expression transcriptional stimulation by hormone. regulates at level. A detailed functional protein-DNA footprint analysis elements involved mediating basal presented
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