Impact of early perfusion status of the infarct-related artery on short-term mortality after thrombolysis for acute myocardial infarction: Retrospective analysis of four german multicenter studies

摘要: Objective. This study evaluated the impact of early patency infarct-related vessel on short-term mortality after thrombolysis for acute myocardial infarction. Background. Different thrombolytic regimens infarction proved to be equally effective in large scale trials despite significant differences their efficacy with respect as shown smaller angiographic trials. Methods. Patients from four German multicenter studies were retrospectively evaluated. Of 939 patients (duration symptoms <6 h) treated thrombolysis, 907 (96.6%) had an angiogram artery 90 min initiation therapy. The perfusion status was graded according Thrombolysis Myocardial Infarction (TIMI) criteria. Results. Complete reperfusion (TIMI grade 3) found 561 and partial reperfusiom 2) 122 907. Overall, in-hospital rate 4.6% (43 patients). In complete vessel, only 2.7% versus 7.1% occluded at 90-min angiogram. difference highly univariate well multivariate analysis. infarct 6.6%. Conclusions. is independent predictor survival. However, associated a reduced whereas have prognosis similar that persistently vessels. Therefore, when used surrogate end point mortality, TIMI 3 should interpreted treatment success infarction.