Fiber Intakes and Anthropometric Measures are Predictors of Circulating Hormone, Triglyceride, and Cholesterol Concentrations in the Women's Health Trial

摘要: The unhealthy eating patterns and obesity among women in the U.S. are indicated by changes biomarkers, such as insulin, lipoproteins, estradiol, that risk factors for breast cancer cardiovascular diseases. This article models interrelations diet, serum sex hormone binding globulin (SHBG) concentrations, plasma LDL HDL cholesterol, net triglyceride using data at baseline 12 mo on 379 615 postmenopausal Control Intervention groups, respectively, of Women’s Health Trial: Feasibility Study Minority Populations. Subjects group received detailed advice over a period 1 y reducing fat intakes increasing consumption whole grains fruits vegetables. main findings were there significant differences between groups from to cholesterol SHBG concentrations. Second, comprehensive random effects modeling framework, ratio fiber energy intake was significantly associated (P , 0.05) with lower insulin levels, higher concentration group. Third, subjects’ waist-to-hip BMI SHBG, Fourth, levels negatively positively triglyceride, estradiol Overall, weight loss, especially around waist, increased likely be beneficial lipid, profiles women. J. Nutr. 136: 2249–2254, 2006.