Protection against tissue damage in vivo by desferrioxamine: what is its mechanism of action?
作者： Barry Halliwell
DOI: 10.1016/0891-5849(89)90145-7
关键词: In vivo 、 Radical 、 Eicosanoid 、 Superoxide 、 Mechanism of action 、 In vitro 、 Chelation 、 Deferoxamine 、 Biochemistry 、 Chemistry
摘要: Desferrioxamine (deferoxamine) is an inhibitor of iron-dependent free radical reactions that has been used to investigate the role such in several animal model systems for human disease. In vitro, desferrioxamine not only iron chelator but also binds other metal ions, reacts with superoxide and hydroxyl radicals, affects eicosanoid synthesis, can act as a substrate peroxidases generate reactive nitroxide radical. However, considerations concentration vivo suggest its ability inhibit major factor accounts desferrioxamine's generally-protective action models
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