The iron chelators desferrioxamine and 1-alkyl-2-methyl-3-hydroxypyrid-4-ones inhibit vascular prostacyclin synthesis in vitro.

摘要: The iron chelators desferrioxamine (DFO), 1,2-dimethyl(L1)-, 1-ethyl-2-methyl(L1NEt)- and 1-propyl-2-methyl(L1NPr)-3-hydroxypyrid-4-ones inhibited rat aortic prostacyclin (PGI2) synthesis in vitro (rank order of potency: DFO greater than L1 L1NEt L1NPr) when stimulated with adrenaline, arachidonate the Ca2+ ionophore A23187. inhibitory action was blocked by Fe3+ Al3+ reversed washing H2O2, but not ascorbate. These data suggest that inhibit prostanoid intact tissue through removal or binding linked to cyclo-oxygenase. may be therapeutic value treatment inflammatory other diseases via two mechanisms: (1) inhibition pro-inflammatory (2) toxic-free-radical generation