The effects of an iron chelator on cellular injury induced by vascular stasis caused by hypothermia.
作者： Jaisimha Iyengar , Anna George , John C. Russell , Dipak K. Das
DOI: 10.1016/0741-5214(90)90008-X
关键词:
摘要: Rewarming of a cooled rabbit leg was associated with the generation oxygen-derived free radicals, shown to be instrumental for tissue injury occurring during rewarming. The present study used compound that, by its ability bind iron, can remove hydroxyl radical (OH.) from tissue. Deferoxamine reduced cooling and rewarming, as evidenced decrease release lactic acid dehydrogenase creatine kinase. also formation OH. lipid peroxidation rewarming phase. This did not have any effect on arterial blood flow pattern, which uniformly decreased restored results this indicate efficacy deferoxamine in reducing cellular cold further suggest role radicals pathophysiology cold-rewarming injury.
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