Familial testicular cancer and urogenital developmental anomalies.

摘要: In a case-control study of testicular cancer, 6 269 cases (2.2%) reported first-degree relative with compared to 1 259 controls (0.4%). Fathers and brothers cancer had six-fold elevated risk developing malignancy men in the general population. Cryptorchidism was (17%) familial versus 7 (2.7%) 14 263 (5.3%) negative family history for cancer. One half groin hernia (all surgically repaired before age 12), 12.7% 10.3% nonfamilial cases. Three clusters identified through were selected clinical evaluation. surviving males these 3 families undergone orchiopexy inguinal herniorrhaphy at years, one hydrocele associated his tumor. Of 12 living fathers men, childhood hernias, two coexisting hydroceles. additional hydroceles detected during urologic evaluation healthy relatives. The high prevalence cryptorchidism, among suggests that an underlying alteration urogenital embryogenesis may be predisposition neoplasia.