Beta-Band Resonance and Intrinsic Oscillations in a Biophysically Detailed Model of the Subthalamic Nucleus-Globus Pallidus Network

摘要: Increased beta-band oscillatory activity in the basal ganglia network is associated with Parkinsonian motor symptoms and suppressed medication deep brain stimulation (DBS). The origins of oscillations, however, remains unclear both intrinsic oscillations arising within subthalamic nucleus (STN)-external globus pallidus (GPe) exogenous beta-activity, originating outside network, proposed as potential sources pathological activity. aim this study was to explore relative contribution autonomous inputs generation a biophysically detailed model parkinsonian STN-GPe network. accounts for integration synaptic currents their interaction membrane dendritic structures STN GPe. used investigate development synchrony bursting by changing balance excitation inhibition nuclei, adding varying phase relationships through hyperdirect cortico-subthalamic indirect striato-pallidal pathways. showed an susceptibility that manifest weak autonomously generated selective amplification near network's endogenous oscillation frequency. frequency at which resonance peak occurred determined net level excitatory drive Intrinsic or endogenously were too support pacemaker role they considerably amplified sparse cortical beta further striatal promoted anti-phase firing cortex GPe, resulting maximum transient neurons. elucidates mechanism patterning feedback whereby can lead locked spiking under conditions. These results point synchronization, pallido-striatal loop amplifying oscillations.