The pharmacological profile of non-opioid (OTC) analgesics: aspirin, paracetamol (acetaminophen), ibuprofen, and phenazones.

摘要: All non-opioid analgesics are believed to act via inhibition of cyclo-oxygenase. With respect their inhibitory potency towards the enzyme, these drugs differ not only from most non-steroidal anti-inflammatory but also among themselves. The differences appear be some therapeutic relevance. They explain why many unsuitable for over-the-counter (OTC) use and OTC have different profiles effects side effects. In addition, suitability in everyday practice is widely determined by pharmacokinetic parameters. These parameters here compiled aspirin, paracetamol (acetaminophen), ibuprofen, metamizol (dipyrone), then compared, finally evaluated as implications.