Effect of tacrine on EEG slowing in the rat: enhancement by concurrent monoamine therapy.

摘要: A dominant electrophysiological characteristic of Alzheimer's disease (AD) is the loss desynchronized EEG activity and shift toward low-frequency synchronization. In rats, similar changes resulted from administering anti-cholinergic scopolamine (1 mg/kg) monoamine depletor reserpine (10 mg/kg); amplitude increases between 0.5-20 Hz, with delta (0.5-4 Hz) theta (4-8 bands affected most severely. The acetylcholinesterase inhibitor tacrine, at doses 10 20 mg/kg, reversed these changes; co-administration tacrine noradrenaline-serotonin reuptake imipramine enhanced tacrine's action to suppress activity. Co-administration monoamine-oxidase pargyline (20 restoration by in all frequency 0.5 but selective serotonin fluoxetine (2 was ineffective. These results show that some drug therapies aimed concurrently stimulating cholinergic monoaminergic neurotransmission are more effective reversing slowing than therapy alone. Significant deficits occur disease, addition atrophy neurons. Thus, combined cholinergic-monoaminergic may provide an cortical functioning, limiting required treatment dose cholinesterase inhibitors.