Cholinergic modulation of MEG resting-state oscillatory activity in Parkinson's disease related dementia.

摘要: Abstract Objective EEG and MEG studies in Parkinson’s disease (PD) related dementia (PDD) have shown a slowing of resting-state, oscillatory activity compared to non demented PD. Aim the present study was determine whether treatment with cholinesterase inhibitor rivastigmine would reverse this resting-state PDD patients. Methods In eight patients, whole head recorded condition before after rivastigmine. Relative spectral power calculated delta, theta, alpha, beta gamma frequency bands fronto-central, parieto-occipital temporal regions. Results After rivastigmine, patients demonstrated an increase relative alpha range regions together diffuse power. Furthermore, decrease delta fronto-central found. Conclusions Treatment at least partly counteracts brain that is known occur PD dementia. Significance Our observations emphasize prominent role degeneration cholinergic system pathophysiology future, might contribute selection who may optimally benefit from treatment.