Modeling immunocompetence development and immunoresponsiveness to challenge in chicks

摘要: The purpose of this study was 2-fold: 1) to develop a deterministic model that describes the development immunocompetence and kinetics immunoresponsiveness pathogenic challenge in chicks 2) use illustrate importance factors experimental design, such as type variable measured, measurement timing, age. Difficulties evaluating immunological variables hinder attempts improve animal health through selection on variables. In young chicks, is additionally complicated by immune system maternal immunity. evaluation definition appropriate strategies may be enabled mathematical captures key components its development. Therefore, developed well extracellular bacterial an individual chick from 0 56 d consisted 4 describing (maternal baseline immunity) (acute phase antibody response). Individual component equations generally fit published data adequately. Four scenarios represented combinations age timing were simulated. each scenario, particular compared for 3 different levels immunity, representing broiler genotypes. It illustrated design (type age) can have important effect ranking genotypes, groups, or individuals reliability extrapolations based ranking. concluded potentially useful tool when immunoresponsiveness. Further, it used generator hypotheses global relationships tested experimentally.