Influenza vaccination reduces hemorrhagic stroke risk in patients with atrial fibrillation: A population-based cohort study

摘要: Abstract Purpose The risk of hemorrhagic stroke in patients with atrial fibrillation (AF) is low but the consequences its occurrence are extremely severe. In this study, we investigated association influenza vaccination to develop an efficient strategy for reducing AF. Methods data were retrieved from Taiwan National Health Insurance Research Database. study cohort comprised all who received a diagnosis AF ( n =14,454) before January 1, 2005 (index date) and followed until December 31, 2012. Propensity scores calculated using logistic regression model determine effects by accounting covariates that predict receiving intervention (vaccine). A time-dependent Cox proportional hazard was used calculate ratios (HRs) vaccinated unvaccinated Results population 6570 did (2547 [38.77%]) not receive (4023 [61.23%]) vaccination. adjusted HRs (aHRs) lower than (influenza season, noninfluenza seasons: aHRs=0.97 [0.59–1.60], 0.51 [0.30–0.87], 0.72 [0.50–1.03], respectively). Conclusions Influenza exerts dose–response synergistic protective against have high (i.e., male sex, age≥75years, Charlson comorbidity index ≥3, hypertension) reduces incidence stroke.