Molecular and cellular pathogenesis of adamantinomatous craniopharyngioma

摘要: Adamantinomatous craniopharyngiomas (ACPs) are the most common pituitary tumours in children. Although histologically benign, these clinically aggressive tumours, difficult to manage and associated with poor quality of life for patients. Several human mouse studies have provided unequivocal evidence that over-activation WNT/β-catenin signalling pathway underlies molecular aetiology tumours. Recently, research using genetically modified models ACP revealed a critical unexpected non-cell autonomous role stem cells tumourigenesis, which has expanded cancer cell paradigm. As result this basic research, pathogenesis is being unveiled, promising implications development novel treatments against childhood neoplasms. These benign may additionally represent unique model provide insights into initial steps oncogenesis.