Synthesis and biological activity of pyrimido (1, 2 -a) quinoline moiety and its 2-substituted derivatives
作者： A G Jadhav , N K Halikar
DOI: 10.1088/1742-6596/423/1/012007
关键词: Aniline 、 Methylene 、 Medicinal chemistry 、 Quinoline 、 Malononitrile 、 Chemistry 、 Organic chemistry 、 Moiety 、 Amine gas treating 、 Potassium carbonate 、 Methyl group
摘要: 2-Amino-3-cyano quinoline (1) and bis (methylthio) methylene malononitrile (2) were refluxed in N,N-dimethyl formamide (DMF) presence of catalytic amount anhydrous potassium carbonate to afforded 3, 11-dicyano-4-imino-2-methylthio -4H-pyrimido [1, 2-a] (3). The latter further reacted with different substituted aniline, phenol, hetryl amine compound containing active methyl group. Afforded 11-dicyano-4-imino their 2-substuited derivatives (4a-7c). All these newly synthesized compounds characterized by elemental analysis spectral data, screened for antimicrobial activities.
harvard.edu
sci-hub.se 参考文章(20)
T. H. Althuis, P. F. Moore, H. J. Hess, Development of ethyl 3,4-dihydro-4-oxopyrimido[4,5-b]quinoline-2-carboxylate, a new prototype with oral antiallergy activity. Journal of Medicinal Chemistry. ,vol. 22, pp. 44- 48 ,(1979) , 10.1021/JM00187A011
Haythem Saadeh, Ibrahim Mosleh, Mohammad Mubarak, Synthesis of novel hybrid molecules from precursors with known antiparasitic activity. Molecules. ,vol. 14, pp. 1483- 1494 ,(2009) , 10.3390/MOLECULES14041483
K. N. Dhawan, B. P. Jaju, G. P. Gupta, Validity of antagonism of different effects of reserpine as test for anti-depressant activity. Psychopharmacology. ,vol. 18, pp. 94- 98 ,(1970) , 10.1007/BF00402388
Jochen Wiesner, Regina Ortmann, Hassan Jomaa, Martin Schlitzer, New Antimalarial Drugs Angewandte Chemie International Edition. ,vol. 42, pp. 5274- 5293 ,(2003) , 10.1002/ANIE.200200569
I. V. Ukrainets, Liu Yangyang, A. A. Tkach, A. V. Turov, 4-HYDROXY-2-QUINOLONES 166*. SYNTHESIS, ISOMERISM, AND ANTITUBERCULAR ACTIVITY OF 3-ARYLAMINOMETHYLENE- QUINOLINE-2,4-(1H,3H)-DIONES Chemistry of Heterocyclic Compounds. ,vol. 45, pp. 802- 808 ,(2009) , 10.1007/S10593-009-0356-X
C. H. Browning, J. B. Cohen, S. Ellingworth, R. Gulbransen, The antiseptic action of anil-pyridines and anil-quinolines The Journal of Pathology and Bacteriology. ,vol. 27, pp. 121- 122 ,(1924) , 10.1002/PATH.1700270115
Maher F. El-Zohry, Abd El-Hamed N. Ahmed, Farghaly A. Omar, Mohamed A. Abd-Alla, Synthesis and antibacterial activity of certain quinoline and quinazoline derivatives containing sulfide and sulfone moieties. Journal of Chemical Technology & Biotechnology. ,vol. 53, pp. 329- 336 ,(2007) , 10.1002/JCTB.280530403
Mark P. Wentland, Suzanne C. Aldous, Monte D. Gruett, Robert B. Perni, Ronald G. Powles, Deborah W. Danz, Kristina M. Klingbeil, A.Danielle Peverly, Ronald G. Robinson, Thomas H. Corbett, James B. Rake, Susan A. Coughlin, The antitumor activity of novel pyrazoloquinoline derivatives Bioorganic & Medicinal Chemistry Letters. ,vol. 5, pp. 405- 410 ,(1995) , 10.1016/0960-894X(95)00044-T
A.Z.M. Shaifullah CHOWDHURY, Yasuyuki SHIBATA, Synthesis of new fused pyrimidines by isocyanate and isothiocyanate. Chemical & Pharmaceutical Bulletin. ,vol. 49, pp. 391- 395 ,(2001) , 10.1248/CPB.49.391
Hailin Zheng, Lev M. Weiner, Orit Bar-Am, Silvina Epsztejn, Z. Ioav Cabantchik, Abraham Warshawsky, Moussa B.H. Youdim, Mati Fridkin, Design, synthesis, and evaluation of novel bifunctional iron-chelators as potential agents for neuroprotection in Alzheimer’s, Parkinson’s, and other neurodegenerative diseases Bioorganic & Medicinal Chemistry. ,vol. 13, pp. 773- 783 ,(2005) , 10.1016/J.BMC.2004.10.037