4-HYDROXY-2-QUINOLONES 166*. SYNTHESIS, ISOMERISM, AND ANTITUBERCULAR ACTIVITY OF 3-ARYLAMINOMETHYLENE- QUINOLINE-2,4-(1H,3H)-DIONES
作者： I. V. Ukrainets , Liu Yangyang , A. A. Tkach , A. V. Turov
DOI: 10.1007/S10593-009-0356-X
关键词:
摘要: Condensation of 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carbaldehydes, thioglycolic acid (or methyl thioglycolate), and anilines does not lead to the synthesis corresponding thiazolidinylquinolones because Schiff bases so formed exist exclusively in a form inert enamine thioglycolates. 1 H NMR spectroscopy showed that main components isolated 3-arylaminomethylenequinoline-2,4-(1H,3H)-diones are E-isomers. The results study antitubercular properties compounds obtained presented.
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