Synthesis and Antimicrobial Activity of 3-Cyano-4-imino-9-methoxy-4H-pyrimido [2, 1-b] pyrimido [4, 5-b] quinoline and 2-Substituted Derivatives
作者： S. P. Vartale , N. K. Halikar , Y. D. Pawar
DOI: 10.1155/2013/862651
关键词: Quinoline 、 Aryl 、 Antimicrobial 、 Catalysis 、 Organic chemistry 、 Methylene 、 Alcohol 、 Phenols 、 Chemistry 、 Malononitrile
摘要: The 2-amino-7-methoxypyrimido[4,5-b]quinoline (1) on treatment with bis(methylthio)methylene malononitrile (2) in ethyl alcohol and catalytic amount of TEA gives 3-cyano-4-imino-9-methoxy-2-methythio-4H-pyrimido[2,1-b]pyrimido[4,5-b]quinoline (3). latter were further reacted selected N-, O-, C-nucleophiles such as aryl amines, hetryl substituted phenols, compounds containing an active methylene group.
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