Methods and compositions for regulating lymphocyte activity
作者： Tessa Crompton
DOI:
关键词: Cell biology 、 Hedgehog signaling pathway 、 Smoothened 、 Biochemistry 、 Lymphocyte 、 Signal transduction 、 Patched 、 Signalling 、 Hedgehog 、 Biology
摘要: The present application is directed to the discovery that hedgehog gene products, and signal transduction pathways involving hedgehog, are involved in maturation of T lymphocytes. Certain aspects invention preparations polypeptides, agonists, antagonists, or other molecules which regulate patched smoothened signalling, their uses as immunomodulatory agents.
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